Method of preparing &#34;zingiberone.&#34; (methyl s-methoxy-4-hydroxyphenyl-ethyl ketone.)



lUTNllTEU *neesm me in? smmm, JAPAN;

METHOD or PREPARING ezmemmtounfi (METHYL 8-1VETHOXYJLHYDROXYPHEIVYL- l :ETHYL ETONE.) "1

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No Drawing.

To all whom it may conceqm:

Be it known that I, fessor of chemistry, a subject of the Empcre'r of J apan, residing at No. 30 Kudun, city of 5 Sendai, Miyagi. Prefecture, Empire of Japan, have invented a certain new Method of Preparing Zingiberone, 0xy-4-Hydr0Xypheny1ethyl Ketongl a, pun gent principle of ginger-root, (Zing'lber offi The procedure is for instance as foile'ufez 1 VamZZaZa0et0nc.-

a 0cn3 micncocne i 70 c. of 10% caustic soda solution were added to the solution 01" grulnsel m, nillm. in 100 c. e. of acetone, and ether 0 grams of vanillnlacetene were suspended in 100 e c. at ebselute ether and redueed by fipecification of Letters Patent.

Hmosm NOMURATPQHY);

(Methyl 3-Meth ing allowed to stand for four days, the 50- ital ' lP'iEiVBlllilMll n w}. 23, iwido Application filed June 6,1917. Serialfile. 173,114.

.cutien." i 1 I have feuud um ningihercueis easily prepu'red by the reduction; of v zmillalecetone which is" Obtained by the condensation of mui'llin; null :iceh'me iii-presence of caustic ullmli, the process he-iug illustrated in the felhnviiig l v v cindle,) of which the following" is a specifiunencecm A 011 011 80011 f unillulucelene. E

Ziuggiherenef 11mm e'l' hvdi'egg eu .iu the presence Of p1uti-- ulm 'hhwl. 'lhe h x whegnau absorbed was :1lmul 800. :(Iul 23121- and 7: i--75 l 1n1u.) for nine h ui:-:.- i' t'lleulilleiiun; ill the'phlti- 'uu-m hhu-lc, the lill -u t e mu! elfh'erezil washings of (he plutimuu.hhwk wereevaporated :uul l he re hlunl nil uu diwtilhilziqu hiiiled coustruul-y :1: 1H? d mule! ll u in'i. "'lheyield mums. 'lhe uil uus tu ice recryslulli ml New :1 mixture of clheruud' petroleum :rihel' ll. it. helow (30). The crystals thus ehluinwl melted at 40-41 and were analyzed \vil h ihe following results:

01020 gun- 01058 (10, and 0.1090 H U.

1' in time p 011') ave 05113 CU, and 0.0850 HZU.

a; l: 47m.

The sulmlzmcc produced no lowering of {he ineltlug pelut by mixing with the natuml mnglheronc. The heumyl derivative root (Zingz'bar ofii'ci'nale) having the constitutional lormula,

GI-I CII COCH'; Zingiherone.

eoinprising adding an alkaline solution'to a solu ion of vanillin and acetone, then acidil' ving the solution to obtain a precipitate, then dissolving the precipitate in a solvent and er v tallizing the vanillalacetone out of the solution. then dissolving the vanillalacetone er vslals in a solvent and reducing the solution by means of hydrogen in the pres enee ol' platinum black, filtering ol't' the platinum black, then evaporating the filtrate to an oil, then distilling the oil, then dissolving the distillate. in a solvent and finally crystallizing the zin'giberone out of the solution.

The. method of preparing zingiberon eoniprising adding an alkaline solution to a solution of vanillin and acetone, then acidifying the solution to obtain a precipitate, then dissolving the. preci 'litate in a solvent and envstallizing the vanilla]acetone out of the solution. then dissolving the vauillalaeetone tl' l:ll$ in ether. then reducing the solulion by means ol' hydrogen in the presence o'l' platinuililaek, then filtering oil the platinum black, then evaporating the liltrate to an oil, then distilling the oil, then dissolving the distillate in a mixture oi ether and petroleum ether. and tinall trystallizing-the zingiherone out ot' the solution.

2). The method ol preparing zingilua'one comprising adding a 10% solution of caustic soda to a solution of vanillin and acetone and allowing the same to stand, then add ing hydrochloric acid to the solution to obtain a precipitate, then filtering and washing the precipitate, then dissolving the precipitate in alcohol, then crystallizing the vanillalacetone out of the solution, then dissolving the vanillalacetono crystals in a solvent and reducing the solution by means of hydrogen in the presei'iee of platinum black, littering ofi' the. platinum black, then evaporating the filtrate to an oil, then distilling the oil. then dissolving the distillate in a solvent and finally erystallizing the, zingilierone out. of the solution.

The method oil preparing Zingiherone eomprising adding a 10% solution of canstic soda to a solution ol \Ianillin and acetone and allowing the saute to stand, then adding hydrochloric acid to the solution to obtain a preeipilate, then littering and Wasll- .ing the precipitate, then dissolving the pre cipitate .in alcohol, then crystallizin the vanilialaeett'me out of the solution, then dissolving the. vanillalaeetone crystals in ther, then reducing the solution by meansv ot' hy drogen in the presence of platinum lilttt'li, then littering oil the platinum hlaek, then evaporating the filtrate to an oil, then di tilling the oil, th n dissolving the distillate in a mixture of ether and petroleum ether and lmallv urystallizing the zingiheror out, of the solution.

1n t stimony whereof I atlix my signature in present-e of two witnesses.

lllltOSl'll NOMURA. Wit nesses:

ill. 1*. llan'nny, .l\I. Monument.

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